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Graft-vs.-host disease

S B Woo1, S J Lee, M M Schubert

  • 1Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists
|January 1, 1997
PubMed
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It is time to move on.....

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Bone marrow transplantation (BMT) is crucial for treating various cancers and disorders. Oral graft-vs-host disease (GVHD) is a common complication, presenting unique challenges and requiring specific management strategies.

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Bone marrow transplantation (BMT) is a vital treatment for hematologic malignancies, bone marrow failure, and immunodeficiencies.
  • Unrelated allogeneic BMT is increasingly common due to established marrow banks.
  • Graft-vs-host disease (GVHD) is a significant complication, affecting 25-70% of patients.

Purpose of the Study:

  • To discuss general principles of BMT.
  • To outline systemic and local therapeutic options for oral GVHD.
  • To highlight the oral manifestations of acute and chronic GVHD.

Main Methods:

  • Review of general BMT principles.
  • Discussion of systemic therapeutic options for oral GVHD.
  • Description of local therapeutic interventions for oral GVHD.

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Main Results:

  • Oral GVHD manifests differently in acute (erythematous, ulcerative) and chronic (lichenoid) forms.
  • Chronic oral GVHD can lead to sicca syndrome, xerostomia, and salivary gland atrophy.
  • GVHD remains a frequent complication despite prophylaxis.

Conclusions:

  • Oral GVHD presents distinct clinical features in acute and chronic phases.
  • Management strategies for oral GVHD involve both systemic and local treatments.
  • Understanding oral manifestations is key to managing GVHD post-BMT.