Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Matrigel: a useful tool to study endothelial differentiation

S Baatout1, N Cheţa

  • 1Laboratory of Hematology, U. C. L. (Université Catholique Louvain), Yvoir, Belgium.

Romanian Journal of Internal Medicine = Revue Roumaine De Medecine Interne
|July 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Joint research towards a better radiation protection-highlights of the Fifth MELODI Workshop.

Journal of radiological protection : official journal of the Society for Radiological Protection·2014
Same author

520-d Isolation and confinement simulating a flight to Mars reveals heightened immune responses and alterations of leukocyte phenotype.

Brain, behavior, and immunity·2014
Same author

Biological carrier molecules of radiopharmaceuticals for molecular cancer imaging and targeted cancer therapy.

Current pharmaceutical design·2014
Same author

Transgenerational developmental effects and genomic instability after X-irradiation of preimplantation embryos: studies on two mouse strains.

Mutation research·2010
Same author

Controlled light exposure microscopy reveals dynamic telomere microterritories throughout the cell cycle.

Cytometry. Part A : the journal of the International Society for Analytical Cytology·2008
Same author

Genrisk-T project: response of the TPC-1 papillary thyroid carcinoma cell line to a range of low to high doses of irradiation.

Communications in agricultural and applied biological sciences·2008

Matrigel, a basement membrane matrix, promotes endothelial cell differentiation and reduced proliferation. This makes it a valuable model for studying angiogenesis and extracellular matrix roles.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Extracellular Matrix Research

Background:

  • Matrigel is derived from a mouse basement membrane neoplasm.
  • It comprises key proteins like laminin and type IV collagen, plus growth factors.

Purpose of the Study:

  • To present Matrigel as a model for studying angiogenesis.
  • To investigate the role of the extracellular matrix in angiogenesis.

Main Methods:

  • Induction of endothelial cell differentiation using Matrigel.
  • Observation of morphologic changes and proliferation rates.

Main Results:

  • Matrigel induces endothelial cell differentiation.
  • Matrigel leads to reduced endothelial cell proliferation.

Related Experiment Videos

Conclusions:

  • Matrigel serves as a practical model for studying angiogenesis.
  • It facilitates research into extracellular matrix contributions to angiogenesis.