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Related Experiment Videos

Malignant blue naevus with distant subcutaneous metastasis

R Böni1, R Panizzon, R A Huch Böni

  • 1Department of Dermatology, University Hospital of Zurich, Switzerland.

Clinical and Experimental Dermatology
|November 1, 1996
PubMed
Summary

Malignant blue nevus, a rare melanoma variant, can recur. Increased Ki-67 expression in cellular blue nevi may indicate malignant and metastatic potential, aiding early detection.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Malignant blue nevus is a rare variant of malignant melanoma.
  • Cellular blue nevi are typically benign but can rarely transform.
  • Early identification of malignant potential is crucial for patient outcomes.

Observation:

  • A case of a suprapatellar cellular blue nevus with triple recurrence over 12 years is presented.
  • Staging revealed a distant subcutaneous metastasis.
  • Immunohistochemistry confirmed S-100, HMB-45, NKI/C-3 positivity in the primary and recurrent lesions.

Findings:

  • The malignant lesions showed positive Ki-67 staining.
  • Non-malignant cellular blue nevi from other patients were Ki-67 negative.
  • A shift from negative to positive Ki-67 expression was observed.

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Implications:

  • Ki-67 expression may serve as a valuable marker for assessing malignant and metastatic potential in cellular blue nevi.
  • This finding could aid in the early diagnosis and management of potentially aggressive blue nevi.
  • Further research is warranted to validate Ki-67 as a predictive biomarker.