Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A method for calibrating three-dimensional positron emission tomography without scatter correction

D L Bailey1, T Jones

  • 1MRC Cyclotron Unit, Hammersmith Hospital, DuCane Rd., London, W12 0HS, UK.

European Journal of Nuclear Medicine
|June 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-centre experience with peptide receptor radionuclide therapy for neuroendocrine tumours (NETs): results using a theranostic molecular imaging-guided approach.

Journal of cancer research and clinical oncology·2023
Same author

Partial volume effect in SPECT & PET imaging and impact on radionuclide dosimetry estimates.

Asia Oceania journal of nuclear medicine & biology·2023
Same author

Practical learning through radiation physics problem solving.

Radiography (London, England : 1995)·2022
Same author

Theranostic SPECT reconstruction for improved resolution: application to radionuclide therapy dosimetry.

EJNMMI physics·2021
Same author

Obesity alters the topographical distribution of ventilation and the regional response to bronchoconstriction.

Journal of applied physiology (Bethesda, Md. : 1985)·2019
Same author

Combined PET/MRI: Global Warming-Summary Report of the 6th International Workshop on PET/MRI, March 27-29, 2017, Tübingen, Germany.

Molecular imaging and biology·2017
Same journal

[Not Available].

European journal of nuclear medicine·2016
Same journal

A Window on Latin America.

European journal of nuclear medicine·2016
Same journal

Erratum: Eur J Nucl Med (1999) 26: 686-692.

European journal of nuclear medicine·2016
Same journal

Nuclear medicine in the next decade.

European journal of nuclear medicine·2014
Same journal

Erratum: Impact of attenuation correction on the accuracy of FDG-PET in patients with abdominal tumors: a free-response ROC analysis.

European journal of nuclear medicine·2014
Same journal

(99m)Tc(V)DMSA quantitatively predicts (188)Re(V)DMSA distribution in patients with prostate cancer metastatic to bone.

European journal of nuclear medicine·2014
See all related articles

A new calibration method for 3D Positron Emission Tomography (PET) eliminates the need for scatter and attenuation correction. This approach enhances the accuracy and applicability of PET imaging across different body regions.

Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Physics

Background:

  • Accurate calibration of 3D Positron Emission Tomography (PET) systems is crucial for quantitative imaging.
  • Traditional calibration methods rely on corrections for scatter and attenuation, which can introduce inaccuracies and limit applicability.
  • The effectiveness of scatter correction varies across different body regions, posing challenges for consistent calibration.

Purpose of the Study:

  • To develop a novel calibration method for 3D PET that is independent of scatter and attenuation correction.
  • To extend a previously described method for absolute sensitivity measurement to provide an "in air" calibration for PET cameras.
  • To enable accurate activity concentration measurements in reconstructed 3D PET images.

Main Methods:

Related Experiment Videos

  • A calibration method was developed that bypasses the need for scatter and attenuation correction.
  • The method was applied to measure the "in air" calibration factor in units of kBq/pixel.
  • This factor is used to multiply reconstructed images, yielding accurate activity concentrations.
  • The approach was validated using a fully 3D filtered backprojection algorithm and iterative convolution-subtraction scatter correction on an ECAT 953B system.

Main Results:

  • The developed method provides a practical means of calibrating 3D PET systems without scatter or attenuation correction of calibration data.
  • 3D PET images were calibrated to within +/-5% accuracy.
  • The accuracy achieved is significantly influenced by the precision of the scatter correction applied to the actual imaging data.

Conclusions:

  • A novel, practical calibration method for 3D PET has been established.
  • This method offers general applicability and independence from specific scatter correction techniques.
  • It simplifies the calibration process, improving the reliability of quantitative PET imaging.