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Related Experiment Video

Updated: Jul 8, 2026

Immuno-fluorescence Assay of Leptospiral Surface-exposed Proteins

Immuno-fluorescence Assay of Leptospiral Surface-exposed Proteins

Published on: July 1, 2011

Adherence of Mycoplasma gallisepticum involves variable surface membrane proteins

A Athamna¹, R Rosengarten, S Levisohn

¹Department of Membrane and Ultrastructure Research, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.

Infection and Immunity

|June 1, 1997

Summary

Mycoplasma gallisepticum binds to red blood cells using surface proteins that frequently change. This high-frequency phase variation in membrane proteins mediates adherence to chicken and human erythrocytes.

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Area of Science:

Microbiology
Cell Biology
Immunology

Background:

Mycoplasma gallisepticum is a significant avian pathogen.
Understanding the mechanisms of M. gallisepticum adherence is crucial for controlling infections.

Purpose of the Study:

To investigate the molecular mechanisms underlying the adherence of Mycoplasma gallisepticum to erythrocytes.
To identify the specific M. gallisepticum components involved in erythrocyte binding.

Main Methods:

Colony immunoblotting
Detergent phase fractionation
Trypsin treatment
Comparative proteomic analysis of hemadsorption-positive and -negative mutants

Main Results:

Adherence to both chicken and human erythrocytes is mediated by surface-exposed membrane proteins.
These binding proteins exhibit high-frequency phase variation.

Conclusions:

Surface membrane proteins undergoing phase variation are key mediators of Mycoplasma gallisepticum adherence to erythrocytes.
This mechanism likely contributes to the pathogen's ability to evade host immune responses.