Predictors of permanence of successful radiofrequency lesions created with controlled catheter tip temperature

Transient interruption of accessory pathway (AP) conduction is often encountered during creation of RF lesions, with return of conduction after seconds to weeks. Maximum catheter tip temperature (Tmax) has not been shown to be a good predictor of successful RF ablation. However, other indices related to catheter tip temperature (T) may predict permanent AP interruption. Ninety-one successful RF applications in 58 patients (mean age 11.9 +/- 5.5 years, 38 WPW syndrome, 18 concealed AP, 2 both) were reviewed retrospectively. Forty-two RF applications were transiently successful, with a median time of AP conduction recurrence of 120 seconds (sec; range, 1 sec to > 1 day). This group was compared with 49 permanently successful RF applications. T was measured and controlled using the Medtronic Atakr system (San Jose, CA, USA). RF lesion duration, power output, Tmax and time to Tmax (tmax) were not significantly different between the two groups. By univariate analysis, each of the following indices was able to discriminate between the transient and permanent lesions, and highly correlated with one another, T at the moment of AP interruption (Tsucc; transient 55.0 +/- 7.9 degrees C vs permanent 49.8 +/- 7.7 degrees C, P = 0.0025), time to success (tsucc; transient 4.0 +/- 3.0 sec vs permanent 1.8 +/- 1.3 sec, P = 0.0001), ratio of Tsucc/Tmax (transient 0.76 +/- 0.23 vs permanent 0.57 +/- 0.27, P = 0.0007) and ratio of tsucc/tmax (transient 0.91 +/- 0.69 vs permanent 0.41 +/- 0.41, P = 0.0001). By logistic regression analysis, no single variable or combination of variables was superior to tsucc for prediction of outcome, with a breakpoint of 2.3 seconds having a sensitivity of 74% and a specificity of 65%. During temperature controlled RF application, indices of time and temperature were well-correlated with permanent elimination of AP conduction. Time to interruption of AP conduction < 2.3 seconds after the onset of RF application was predictive of the permanence of successful RF applications. Known relations between RF lesion volume and catheter tip temperature suggest that early conduction block may be an indicator of anatomical proximity of the catheter tip and the AP. These data suggest that, in conjunction with electrogram criteria, selection criteria for optimal sites for RF, application may continue to be refined after the onset of RF application, and support the practice of terminating RF application if AP conduction is not rapidly interrupted.