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A murine model of laparoscopic-assisted intervention
J D Allendorf1, M Bessler, R L Whelan
1Department of Surgery, Atchley Pavilion 522, Columbia University, 161 Fort Washington Avenue, New York, NY 10032, USA.
Surgical Endoscopy
|June 1, 1997
Summary
This study presents a simple, reproducible mouse model for laparoscopic-assisted colon resection. The model is easy to learn and has low complication rates, making it suitable for surgical research.
Area of Science:
- Minimally Invasive Surgery
- Surgical Innovation
- Animal Models
Background:
- Establishing reliable and economical animal models is crucial for studying laparoscopic surgery.
- A novel mouse model for laparoscopic-assisted colon resection is described.
Purpose of the Study:
- To present a reproducible and cost-effective mouse model for laparoscopic-assisted colon resection.
- To facilitate research comparing laparoscopic and open surgical techniques.
Main Methods:
- The model involves insufflating the peritoneal cavity with carbon dioxide and using a 4-mm rigid scope.
- A second port allows for exteriorization, ligation, and resection of the cecum.
- The procedure is completed by returning the cecal stump and closing abdominal wall defects.
Main Results:
- The laparoscopic model is easily mastered, even by individuals with limited surgical experience.
- Intraoperative complication rates were comparable to open surgery (3.2% vs. 2.1%).
- No postoperative leaks were observed in either group, with no deaths in the laparoscopic group.
Conclusions:
- This laparoscopic-assisted colon resection model in mice is a valuable tool for research.
- It provides a reliable platform for comparing the effects of open versus laparoscopic surgery.
