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In vivo fluorescence imaging for tissue diagnostics

S Andersson-Engels1, C Klinteberg, K Svanberg

  • 1Lund University Medical Laser Centre, Sweden.

Physics in Medicine and Biology
|May 1, 1997
PubMed
Summary

Non-invasive fluorescence imaging offers in vivo diagnostic potential across medical fields. This review explores techniques, endogenous and exogenous fluorophores, and clinical applications for tissue characterization.

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Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Spectroscopy

Background:

  • Non-invasive fluorescence imaging provides in vivo diagnostic information for diverse clinical specialties.
  • Research is driven by advancements in photodynamic therapy and the importance of tissue autofluorescence.

Purpose of the Study:

  • To discuss the potential of fluorescence spectroscopy for tissue characterization.
  • To review imaging techniques for diagnostic information extraction.
  • To present the development of exogenous fluorophores for tissue imaging.

Main Methods:

  • Review of literature on fluorescence imaging techniques for tissue diagnostics.
  • Discussion of endogenous molecule fluorescence (autofluorescence).
  • Presentation of exogenous fluorophore development.

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Main Results:

  • Exploration of various fluorescence imaging techniques for tissue characterization.
  • Consideration of both endogenous and exogenous fluorophores.
  • Overview of current clinical evaluation status and future research directions.

Conclusions:

  • Fluorescence imaging, utilizing endogenous and exogenous fluorophores, holds significant promise for in vivo tissue characterization and diagnostics.
  • Further clinical evaluation and development of advanced techniques are crucial for realizing its full potential.