Related Experiment Video
Updated: Aug 15, 2026

Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs
Published on: December 9, 2010
[Surface-active substances in the arsenal of agents against AIDS]
Abstract:
Only nucleoside analogues such as zidovudine have been widely used to improve the clinical state of patients with AIDS till now. Their use has a number of eliminations. Nevertheless, the anti-HIV properties of many different substances have been shown. Some of them contain hydrophobic and polar parts of molecules and can be considered as surfactants. Detergents (DT) (among them Ukrainian preparation Myramistin), modified phospholipids, polyene antibiotics (such as Nystatin A), lipophilic muramyl peptides (LMP), saponins (S) and some other surfactants have been described as inhibitors of HIV replication. Moreover, LMP and S are the potent adjuvants and are probable candidates for vaccines against HIV. Adjuvant activities of some DT have been shown recently as well. We hope that elaboration of new adjuvants with strong anti-HIV properties is an attractive and manageable aim.
Related Concept Videos
Retrovirus Life Cycles
Surface Membrane Barriers
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Sexually Transmitted Infections
Subviral Agents
Antiviral Nucleoside Inhibitors
Inhibitors of Virion Maturation and Assembly

