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Updated: Aug 5, 2026

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
[Cardiomyopexy--current status of an indirect revascularization method]
1Abt. Herzchirurgie, Universitätsklinik Ulm.
This study shows that indirect myocardial revascularization using skeletal muscle flaps effectively relieved angina in patients with severe coronary stenosis. Patients experienced improved exercise tolerance and sustained symptom relief post-procedure.
Area of Science:
- Cardiovascular Surgery
- Regenerative Medicine
- Ischemic Heart Disease
Context:
- Patients with diffuse coronary stenosis unsuitable for traditional bypass surgery often experience severe angina.
- Limited treatment options exist for patients with complex coronary artery disease and heart failure.
Purpose:
- To evaluate the efficacy and safety of indirect myocardial revascularization (myocardioplasty) using free latissimus dorsi muscle flaps.
- To assess the impact of this procedure on angina symptoms and exercise capacity in patients with end-stage coronary artery disease.
Summary:
- Six patients with severe coronary stenosis and angina underwent indirect myocardial revascularization with a free skeletal muscle flap (musculus latissimus dorsi).
- The muscle flap's artery was anastomosed to the aorta, and venous drainage was directed to the right atrium.
- Post-procedure, patients reported significant angina relief within 4 weeks and improved exercise tolerance, with sustained benefits observed in long-term follow-up.
Impact:
- Indirect myocardial revascularization offers a viable alternative for patients with complex coronary artery disease who are not candidates for conventional surgery.
- This technique demonstrates potential for improving myocardial function and quality of life in refractory ischemic heart conditions.
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