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Muscle chemoreflex increases renal sympathetic nerve activity during exercise

K P O'Hagan1, S M Casey, P S Clifford

  • 1Department of Physiology, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois 60515, USA. kohaga@midwestern.edu

Journal of Applied Physiology (Bethesda, Md. : 1985)
|June 1, 1997
PubMed
Summary

The muscle chemoreflex, activated by exercise and hindlimb ischemia, increases sympathetic nerve activity to the kidneys in rabbits. This finding suggests the muscle chemoreflex augments renal sympathetic nerve activity during dynamic exercise.

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Area of Science:

  • Cardiovascular Physiology
  • Autonomic Nervous System Regulation
  • Exercise Physiology

Background:

  • The muscle chemoreflex is known to increase sympathetic drive to skeletal muscles in humans.
  • Understanding its effect on renal sympathetic nerve activity (RSNA) during exercise is crucial for comprehending cardiovascular regulation.

Purpose of the Study:

  • To investigate if activating the muscle chemoreflex augments the renal sympathetic nerve activity (RSNA) response during dynamic exercise in rabbits.
  • To determine the role of the muscle chemoreflex in modulating sympathetic outflow to the kidneys under exercise stress.

Main Methods:

  • Dynamic exercise was performed on a motorized treadmill in rabbits.
  • The muscle chemoreflex was activated using hindlimb ischemia induced by partial aortic occlusion.

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  • Measurements included mean arterial pressure (MAP), heart rate, renal sympathetic nerve activity (RSNA), and terminal aortic blood flow (Qta).

    • Main Results:

    • Exercise alone increased MAP, heart rate, and RSNA.
    • Hindlimb ischemia during exercise evoked a significant pressor response.
    • Muscle chemoreflex activation during exercise led to a marked augmentation of RSNA compared to non-ischemic exercise.

    Conclusions:

    • Activation of the muscle chemoreflex augments sympathoexcitatory drive to the kidney during dynamic exercise.
    • These findings highlight the integrated neural control of circulation during physical exertion.