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Related Experiment Videos

Maximal androgen blockade versus total androgen suppression

H Dumez1, H Van Poppel, L Baert

  • 1Dept. of Oncology and Urology, University Hospitals KULeuven.

Acta Urologica Belgica
|March 1, 1997
PubMed
Summary

Advanced prostate cancer treatment can involve castration and anti-androgens. Low-dose corticosteroids offer a cost-effective option for androgen suppression, yielding secondary remissions in about 30% of patients.

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Area of Science:

  • Oncology
  • Endocrinology

Background:

  • Advanced prostate cancer is initially androgen-dependent and treatable with castration and anti-androgens.
  • Maximal androgen blockade (MAB) is a standard treatment approach.
  • Hormone-refractory prostate cancer presents limited therapeutic options.

Observation:

  • Anti-androgen withdrawal can induce partial remission in some cases of MAB failure.
  • Adrenal androgens contribute to disease progression even after MAB.
  • Corticosteroids can suppress adrenal androgen production.

Findings:

  • Low-dose corticosteroids (hydrocortisone or prednisone) can achieve total androgen suppression (TAS).
  • Approximately 30% of patients with androgen-independent prostate cancer experience secondary remission with low-dose corticosteroids.

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  • This approach has minimal side effects and low cost.

    • Implications:

    • Low-dose corticosteroids represent a viable, cost-effective treatment strategy for hormone-refractory prostate cancer.
    • This offers a valuable therapeutic option when cytostatic agents are limited or ineffective.
    • Further research into corticosteroid mechanisms in prostate cancer is warranted.