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Updated: Aug 5, 2026
Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
Changes in extracellular brain ascorbate in rat striatum in response to administration of non-volatile anaesthetic
Abstract:
We used constant potential in vivo voltammetry to measure changes in striatal ascorbate in the rat in response to i.p. administration of several non-volatile anaesthetics. Propofol and pentobarbitone, which enhance GABA-mediated neuronal inhibitions, decreased ascorbate current to 27.0 (SEM 7.4) % and 46 (6) % of control, respectively. Chloral hydrate, diazepam alone or with ketamine, and fentanyl-fluanisone with midazolam produced no changes in ascorbate current.
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