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Related Experiment Videos

Chloroquine-induced vitiligo-like depigmentation

E Selvaag1

  • 1Department of Dermatology, Ullevaal Hospital, Oslo, Norway.

Annals of Tropical Paediatrics
|March 1, 1997
PubMed
Summary

Chloroquine prophylaxis for malaria can cause temporary facial depigmentation in children with atopic eczema. Symptoms resolved within a year after discontinuing the medication.

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Area of Science:

  • Dermatology
  • Pharmacology
  • Pediatrics

Background:

  • A 6-year-old girl with a history of atopic eczema was prescribed chloroquine for malaria prophylaxis.
  • The patient received 250 mg of chloroquine weekly before traveling to Ethiopia.

Observation:

  • Three weeks after starting chloroquine, the patient developed sharply demarcated depigmentation on her face.
  • The depigmentation was particularly noticeable in the perioral area.

Findings:

  • Discontinuation of chloroquine therapy led to the initial signs of repigmentation within weeks.
  • Complete repigmentation of the affected skin areas was observed one year after stopping chloroquine.

Implications:

  • Chloroquine use may be associated with transient depigmentation, especially in pediatric patients with atopic eczema.
  • This case highlights the importance of monitoring for dermatological side effects during antimalarial prophylaxis in children.
  • Further research may be warranted to understand the mechanism and prevalence of chloroquine-induced depigmentation.

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