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The relation between antioxidants and memory performance in the old and very old
W J Perrig1, P Perrig, H B Stähelin
1Institute of Psychology, University of Berne, Switzerland.
Journal of the American Geriatrics Society
|June 1, 1997
Summary
Higher plasma levels of ascorbic acid and beta-carotene are linked to better memory in older adults. These antioxidant vitamins play a key role in brain aging and may help prevent cognitive decline.
Area of Science:
- Gerontology
- Nutritional Neuroscience
- Cognitive Aging
Background:
- Brain aging is potentially influenced by oxidative stress from free radicals.
- Antioxidant vitamin levels may correlate with cognitive function in healthy elderly individuals.
Purpose of the Study:
- To investigate the relationship between plasma antioxidant vitamin levels and cognitive performance in healthy older adults.
- To examine longitudinal and cross-sectional associations over a 22-year period.
Main Methods:
- A cohort of 442 healthy subjects aged 65-94 years was studied.
- Plasma levels of alpha-tocopherol, ascorbic acid, and beta-carotene were measured in 1971 and 1993.
- Cognitive functions including memory, recognition, and semantic memory were assessed.
Main Results:
- Plasma antioxidant levels showed significant stability over 22 years.
- Ascorbic acid and beta-carotene significantly correlated with free recall, recognition, and vocabulary (semantic memory).
- These antioxidants remained significant predictors of semantic memory after controlling for confounders.
Conclusions:
- Higher plasma ascorbic acid and beta-carotene levels are associated with better memory performance in individuals aged 65 and older.
- Antioxidants play a crucial role in brain aging.
- Findings suggest potential implications for preventing progressive cognitive impairments through antioxidant intake.
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