Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Cholesterol and development]

C Roux1, C Wolf, B Llirbat

  • 1Laboratoire d'Embryologie pathologique expérimentale, CHU Saint-Antoine, Paris.

Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hybrid vesicles from lipids and block copolymers: Phase behavior from the micro- to the nano-scale.

Colloids and surfaces. B, Biointerfaces·2018
Same author

[Erratum to "Histoplasma capsulatum bone and joint infection" [Med. Mal. Infect. 47 (2017) 554-557]].

Medecine et maladies infectieuses·2017
Same author

The divergence history of the perennial plant Linaria cavanillesii confirms a recent loss of self-incompatibility.

Journal of evolutionary biology·2017
Same author

Attachment of Coxiella burnetii to the zona pellucida of in vitro produced goat embryos.

Theriogenology·2017
Same author

FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis.

Oncogene·2017
Same author

[Histoplasma capsulatum bone and joint infection].

Medecine et maladies infectieuses·2017

Distal inhibitors of cholesterol synthesis cause holoprosencephalies. This is linked to Smith-Lemli-Opitz syndrome and Sonic Hedgehog gene function in brain development.

Area of Science:

  • Developmental biology
  • Biochemistry
  • Teratology

Context:

  • Teratogenic effects of distal cholesterol synthesis inhibitors are known.
  • Holoprosencephalies are a specific type of malformation induced by these inhibitors.
  • Recent interest stems from Smith-Lemli-Opitz syndrome and Sonic Hedgehog (Shh) gene involvement.

Purpose:

  • To explore the link between cholesterol synthesis inhibition and holoprosencephalies.
  • To connect teratogenic mechanisms with human genetic disorders.
  • To understand the role of Shh protein in prosencephalon development.

Summary:

  • Distal cholesterol synthesis inhibitors induce holoprosencephalies, a specific developmental defect.
  • The discovery of Smith-Lemli-Opitz syndrome (SLOS) in 1993, a human disorder linked to cholesterol synthesis defects, has renewed interest.

Related Experiment Videos

  • The Sonic Hedgehog (Shh) gene's role in prosencephalon development and Shh protein's "cholesterolisation" process are also key factors.

    • Impact:

    • Provides insights into the etiology of holoprosencephalies.
    • Highlights the critical role of cholesterol in embryonic development.
    • Suggests potential therapeutic targets for developmental disorders.