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Reelin mRNA expression during mouse brain development

S N Schiffmann1, B Bernier, A M Goffinet

  • 1Laboratoire de Recherche sur le Cerveau, Université Libre de Bruxelles, Faculté de Médecine Erasme, Belgium.

The European Journal of Neuroscience
|May 1, 1997
PubMed
Summary
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Reelin, a gene crucial for brain development, is highly expressed in specific neurons and brain regions. Its indirect action, possibly via the extracellular matrix, guides neuronal migration and brain structure formation.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • The reeler mutation in mice causes severe developmental brain abnormalities.
  • Reelin is the gene most likely responsible for the reeler trait.
  • Understanding reelin's expression pattern is key to deciphering its role in brain development.

Purpose of the Study:

  • To map the spatiotemporal expression of reelin mRNA during mouse brain development.
  • To correlate reelin expression with known abnormalities in reeler mutant mice.
  • To elucidate the mechanism of reelin's action in neuronal development.

Main Methods:

  • In situ hybridization was used to detect reelin mRNA expression.
  • Expression levels were analyzed from embryonic day 13 to maturity in mice.

Related Experiment Videos

  • Localization of reelin mRNA was studied across various brain regions.

    • Main Results:

    • Reelin mRNA showed highest expression in Cajal-Retzius neurons.
    • High expression was also observed in the olfactory bulb, cerebellar external granular layer, and early hypothalamic fields.
    • Notably, reelin was absent in radial glial cells and Purkinje cells, areas affected by the reeler mutation.

    Conclusions:

    • Reelin's expression pattern suggests an indirect role in brain development, potentially mediated by the extracellular matrix.
    • Reelin may function as a cell-repulsive molecule, guiding neuronal migration and preventing invasion of specific areas.
    • This mechanism facilitates radial glial cell process deployment and the formation of brain architecture.