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Quantifying Agonist Activity at G Protein-coupled Receptors
11:45

Quantifying Agonist Activity at G Protein-coupled Receptors

Published on: December 26, 2011

Pharmacologic characterization of muscarine receptor subtypes in rat gastric fundus mediating contractile responses

D R Milovanović1, S M Janković

  • 1Department of Pharmacology, Medical Faculty, University of Kragujevac, Serbia, Yugoslavia.

The Indian Journal of Medical Research
|May 1, 1997
PubMed

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Cholinergic agonists or cholinomimetics mimic the action of acetylcholine to stimulate the parasympathetic nervous system. They are categorized into direct-acting and indirect-acting agents. The direct-acting cholinergic drugs induce the parasympathetic response by directly binding to the muscarinic or nicotine receptors. In comparison, the indirect-acting cholinergic drugs prevent acetylcholine hydrolysis, indirectly contributing to the extended parasympathetic response.
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