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Related Experiment Videos

Rat strain and vendor differences in collateral anastomoses

H S Oliff1, P Coyle, E Weber

  • 1Department of Pharmacology, College of Medicine, University of California, Irvine 92697-4625, USA.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|May 1, 1997
PubMed
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Rat strain differences in brain infarct size after middle cerebral artery occlusion are not explained by variations in artery connections. Other factors likely influence lesion volume.

Area of Science:

  • Neuroscience
  • Vascular Biology
  • Comparative Anatomy

Background:

  • Inter- and intrastrain variations in cortical infarct volumes following middle cerebral artery (MCA) occlusion have been observed.
  • Anastomotic variations in collateral blood supply may influence lesion size.

Purpose of the Study:

  • To compare the number and internal diameters of the MCA-anterior cerebral artery (MCA-ACA) anastomoses across different rat strains.
  • To determine if MCA occlusion lesions extend into the ACA territory in specific rat strains/lines.

Main Methods:

  • Four rat strains/lines (Simonsen Sprague-Dawley, Simonsen Wistar, Taconic Sprague-Dawley, Charles River Sprague-Dawley) were used.
  • Arterial visualization was performed using papaverine and white latex injection.
  • MCA occlusion was performed in some rats to assess lesion development and extension.

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Main Results:

  • Significantly fewer MCA-ACA anastomoses were found in Simonsen Sprague-Dawley and Simonsen Wistar rats compared to Charles River Sprague-Dawley and Taconic Sprague-Dawley rats.
  • Mean internal diameters of the anastomoses did not significantly differ between strains.
  • Lesions extended into the ACA territory more frequently in Taconic Sprague-Dawley and Charles River Sprague-Dawley rats after MCA occlusion.

Conclusions:

  • The number and diameter of MCA-ACA anastomoses do not appear to be the primary determinant of differing lesion sizes in these rat strains.
  • Factors beyond anatomical variations in anastomoses likely account for observed differences in cortical infarct volumes after MCA occlusion.