Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytokines and thyroid function

R A Ajjan1, P F Watson, A P Weetman

  • 1Department of Medicine, University of Sheffield, Northern General Hospital, UK.

Advances in Neuroimmunology
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perspective of Continuous Glucose Monitoring-Based Interventions at the Various Stages of Type 2 Diabetes.

Diabetes therapy : research, treatment and education of diabetes and related disorders·2024
Same author

The lived experience of severe mental illness and long-term conditions: a qualitative exploration of service user, carer, and healthcare professional perspectives on self-managing co-existing mental and physical conditions.

BMC psychiatry·2022
Same author

Oral 11β-HSD1 inhibitor AZD4017 improves wound healing and skin integrity in adults with type 2 diabetes mellitus: a pilot randomized controlled trial.

European journal of endocrinology·2022
Same author

Estimated glucose disposal rate as a candidate biomarker for thrombotic biomarkers in T1D: a pooled analysis.

Journal of endocrinological investigation·2021
Same author

Maturity onset diabetes of the young and fibrin-related thrombosis risk.

Diabetes & vascular disease research·2020
Same author

An update on the pathogenesis of Hashimoto's thyroiditis.

Journal of endocrinological investigation·2020
Same journal

Distinct cellular functions mediated by haemopoietic cell-surface proteases.

Advances in neuroimmunology·2020
Same journal

Aging, immunity and neuroendocrine hormones.

Advances in neuroimmunology·1996
Same journal

Dynamic regulation of intestinal immunity by hormones of the hypothalamus-pituitary-thyroid axis.

Advances in neuroimmunology·1996
Same journal

T cell development within the intestinal mucosa: clues to a novel immune-endocrine network?

Advances in neuroimmunology·1996
Same journal

Immunomodulation of peripheral lymphocytes by hormones of the hypothalamus-pituitary-thyroid axis.

Advances in neuroimmunology·1996
Same journal

Autoimmunity to the thyroid stimulating hormone receptor.

Advances in neuroimmunology·1996
See all related articles

Cytokines are key players in autoimmune thyroid disease (ATD), driving inflammation and tissue injury. Research suggests genetic variations and novel cytokine-based therapies for ATD and thyroid-associated ophthalmopathy (TAO).

Area of Science:

  • Immunology
  • Endocrinology
  • Molecular Biology

Background:

  • Cytokines are integral to autoimmune thyroid disease (ATD) pathogenesis.
  • They are produced within the thyroid gland by inflammatory cells and thyroid follicular cells (TFC).
  • Cytokines orchestrate a cascade amplifying the autoimmune response.

Purpose of the Study:

  • To elucidate the multifaceted roles of cytokines in ATD.
  • To explore cytokine involvement in thyroid-associated ophthalmopathy (TAO).
  • To investigate the potential of cytokine-based therapeutics.

Main Methods:

  • Review of existing literature on cytokine mechanisms in ATD.
  • Analysis of cytokine-induced changes in TFC, including MHC and adhesion molecule expression.

Related Experiment Videos

  • Examination of cytokine roles in extrathyroidal manifestations like TAO.

    • Main Results:

    • Cytokines stimulate T and B cells, leading to antibody production and tissue damage.
    • Intrathyroidal cytokines enhance MHC, adhesion, and complement regulatory molecule expression on TFC.
    • Cytokines modulate TFC growth and function, contributing to TAO via fibroblast proliferation and GAG production.

    Conclusions:

    • Cytokines are critical mediators in ATD and its complications, including TAO.
    • Genetic variations in cytokine genes may confer risk for ATD.
    • Emerging evidence supports cytokine-targeted therapies for ATD and TAO.