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Published on: March 29, 2017
Aging, immunity and neuroendocrine hormones
1University of Michigan Medical Center, Department of Pathology, Ann Arbor 48109-0642, USA.
Abstract:
Recent evidence indicates that the neuroendocrine and immune systems are intimately integrated into one system that provides a complex homeostatic network. Disruption of one system by extrinsic factors such as stress or antigenic exposure usually has consequences on the other. With advancing age, a progressive disruption can be observed in both systems which may have profound implications with respect to age-associated pathologies, including autoimmunity. In this review evidence is summarized which supports the hypothesis that neuroendocrine factors influence the age-associated decline of the immune system.
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