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Grouper--creation of marker sets for multiplexed genotyping
1Glaxo Wellcome Research and Development, Bioinformatics Group, Research Triangle Park, NC 27709, USA. rainer_fuchs@glaxowellcome.com
Computer Applications in the Biosciences : CABIOS
|June 1, 1997
Summary
This study introduces Grouper, a software tool that automates the creation of marker sets for high-throughput genotyping. This facilitates multiplexed experiments by organizing polymorphic markers efficiently.
Area of Science:
- Genetics
- Bioinformatics
Background:
- High-throughput genotyping demands multiplexing of polymorphic markers with non-overlapping allele size ranges.
- Efficient marker set arrangement is crucial for multiplexed genotyping experiments.
- Computer software can significantly aid in organizing markers for multiplexing.
Purpose of the Study:
- To describe a software program that automates the generation of marker sets for multiplexed genotyping.
- To provide a tool that facilitates efficient experimental design in high-throughput genotyping.
Main Methods:
- Development of a computer program named Grouper.
- Automation of marker set generation for multiplexed genotyping experiments.
Main Results:
- Grouper successfully automates the creation of marker sets for multiplexed genotyping.
- The software enables efficient organization of polymorphic markers based on allele size ranges.
Conclusions:
- The Grouper program streamlines the process of preparing markers for multiplexed genotyping.
- Availability of such software enhances the efficiency of high-throughput genetic analysis.
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