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Related Experiment Videos

ProMSED: protein multiple sequence editor for Windows 3.11/95

A S Frolov1, I S Pika, A M Eroshkin

  • 1State Research Centre of Virology and Biotechnology Vector, Institute of Molecular Biology, Koltsovo, Russia.

Computer Applications in the Biosciences : CABIOS
|June 1, 1997
PubMed
Summary
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ProMSED is a new software for protein sequence alignment, aiding manual and automatic analysis of distantly related molecules. It facilitates interactive alignment and analysis, improving the discovery of conserved motifs.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Molecular Biology

Background:

  • Protein sequence alignment is crucial for understanding molecular evolution and function.
  • Existing algorithms often require manual refinement for distantly related protein sequences.
  • Interactive alignment software is significant for accurate analysis of divergent sequences.

Purpose of the Study:

  • To introduce ProMSED, a novel MS Windows application for protein sequence alignment.
  • To provide tools for both automatic and manual sequence alignment and analysis.
  • To enhance the interactive alignment process for distantly related proteins.

Main Methods:

  • ProMSED implements the ClustalV algorithm for automatic alignment.
  • The software offers alignment visualization and interactive editing capabilities.

Related Experiment Videos

  • Coloring schemes based on amino acid properties facilitate manual alignment and analysis.

    • Main Results:

    • ProMSED supports multiple sequence formats and features a user-friendly interface.
    • Interactive alignment in ProMSED preserves previously aligned regions.
    • The application successfully identified four out of six conserved motifs in a diverged set of reverse transcriptases.

    Conclusions:

    • ProMSED offers a significant advancement in protein sequence alignment tools.
    • The software effectively combines automatic and manual alignment approaches.
    • ProMSED aids in the discovery of conserved motifs in distantly related proteins.