Related Experiment Videos
[Construction of original artificial immunogens--candidate vaccines against HIV-1]
L R Lebedev1, I P Gileva, L I Karpenko
1State Virology and Biotechnology Center Vektor, Berdsk, Novosibirsk region.
Molekuliarnaia Genetika, Mikrobiologiia I Virusologiia
|September 7, 2000
Abstract:
An original method for making effective artificial vaccines has been developed. Immunogens are virus-like particles containing a DNA molecule covered with recombinant proteins carrying the pathogen epitopes. The recombinant proteins are exposed on the surface of the particle and are attached to DNA via spermidine-polygluquine-glutathione or galactopyranoside conjugates (depending on the hybrid protein composition). Two variants of artificial immunogens-candidates for antiHIV vaccine have been prepared.