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Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future?
M M Teixeira1, R W Gristwood, N Cooper
1Imperial College of Medicine, National Heart and Lung Institute, London, UK.
Trends in Pharmacological Sciences
|May 1, 1997
Abstract:
Phosphodiesterase type 4 (PDE4) plays a major role in modulating the activity of virtually all cells involved in the inflammatory process. Inhibitors of this enzyme family display impressive anti-inflammatory and disease-modifying effects in a variety of experimental models. In this review, Mauro Teixeira, Robert Gristwood, Nicola Cooper and Paul Hellewell examine the capacity of PDE4 inhibitors to exert anti-inflammatory actions in vivo and discuss the potential of this class of drugs to take their place as novel therapeutic agents for a variety of inflammatory diseases.