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Updated: Aug 8, 2026
Transurethral Instillation Procedure in Adult Male Mouse
Published on: November 2, 2017
Transurethral collagen injection for treatment of postprostatectomy urinary incontinence in men
T L Griebling1, K J Kreder, R D Williams
1Department of Urology, University of Iowa, Iowa City 52242-1089, USA.
Objectives:
Transurethral injection of glutaraldehyde cross-linked bovine collagen has recently been advocated as a potentially useful treatment modality for management of urinary incontinence. The reported clinical experience with urethral collagen injection in adult males has been limited.
Methods:
This study summarizes the current literature and reviews the clinical results of collagen injection in a group of 25 men with incontinence after either transurethral or radical prostatectomy.
Results:
The overall results in this series were disappointing. Only 2 patients (8%) achieved significant improvement with this treatment. Eight patients (32%) experienced minimal improvement in symptoms, and 15 (60%) remained incontinent with no improvement in symptoms after collagen injection. The number of injection procedures and volume of collagen material implanted did not correlate with clinical outcome. Five patients (20%) have subsequently required placement of an artificial urinary sphincter to control their incontinence.
Conclusions:
We conclude that transurethral injection of glutaraldehyde cross-linked bovine collagen has a limited role in the management of urinary incontinence in adult men after prostatectomy.
