Related Experiment Videos
[The influence of multiple dialyzer reuse on selected coagulation parameters]
J Juźwiuk1, A Popławski, M Mazerska
1Kliniki Nefrologii Akademii Medycznej w Białymstoku.
Przeglad Lekarski
|January 1, 1997
Summary
Dialyzer reuse in hemodialysis impacts blood clotting. Repeated use affects fibrinogen, platelet counts, and specific clotting factors, indicating potential risks with multiple dialyzer reprocessing.
Area of Science:
- Nephrology
- Hematology
- Biomedical Engineering
Background:
- Dialyzer reuse is a common practice in hemodialysis to reduce costs.
- Potential effects of repeated dialyzer use on patient coagulation parameters require thorough investigation.
Purpose of the Study:
- To evaluate the impact of multiple dialyzer reuse on key coagulation parameters in patients undergoing intermittent hemodialysis.
Main Methods:
- A cohort of 10 hemodialysis patients was studied.
- Coagulation parameters including platelet count, fibrinogen, beta-thromboglobulin (BTG), and platelet factor 4 (PF4) were measured.
- Measurements were taken after the first use and after two subsequent reuses of the dialyzer, manually cleaned with 1% Dialyne solution.
Main Results:
- Fibrinogen concentration increased after 240 minutes of hemodialysis (HD) during the 1st and 3rd dialyzer uses.
- BTG activity showed an increase after 240 minutes of HD when the dialyzer was used for the 3rd time.
- Platelet count decreased after 30 minutes of HD during the 1st and 3rd uses, with the reduction persisting throughout the session on the 3rd use.
- PF4 activity decreased after 30 minutes of HD following the 1st and 2nd dialyzer uses.
Conclusions:
- Multiple dialyzer reuse significantly alters coagulation parameters, including fibrinogen levels and platelet behavior.
- The findings suggest that repeated dialyzer reprocessing may have implications for hemostasis during hemodialysis treatment.