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Updated: Sep 30, 2026

An In Vitro Assay to Detect tRNA-Isopentenyl Transferase Activity
Published on: October 8, 2018
Structure of the human type I iodothyronine 5'-deiodinase gene and localization to chromosome 1p32-p33
T C Jakobs1, M R Koehler, C Schmutzler
1Medizinische Poliklinik, Klinische Forschergruppe, University of Würzburg, Germany.
Abstract:
The human type I iodothyronine 5'-deiodinase gene encodes a member of the family of selenocysteine-containing deiodinases. These enzymes catalyze the activation of the prohormone thyroxine to 3,3',5-triiodothyronine or the degradation of thyroxine and triiodothyronine to inactive metabolites. Here we report the isolation of two genomic type I 5'-deiodinase clones from a chromosome 1-specific gridded cosmid library, the localization of the gene to chromosome 1p32-p33 by fluorescence in situ hybridization, and the determination of the complete structure of the 17.5-kb gene.
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