Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pleuropulmonary amebiasis

K D Lyche1, W A Jensen

  • 1Division of Gastroenterology, University of California San Diego, USA.

Seminars in Respiratory Infections
|June 1, 1997
PubMed
Summary
This summary is machine-generated.

Amebiasis, caused by Entamoeba histolytica, is a major parasitic threat. Invasive amebiasis can lead to severe complications like liver abscesses and pleuropulmonary issues, requiring prompt diagnosis and treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cotton embryogenesis: The entrance and discharge of the pollen tube in the embryo sac.

Planta·2014
Same author

Cotton embryogenesis: The zygote.

Planta·2014
Same author

Cotton embryogenesis: The pollen cytoplasm.

Planta·2014
Same author

Cotton embryogenesis: The tissues of the stigma and style and their relation to the pollen tube.

Planta·2014
Same author

Cotton embryogenesis: The identification, as nuclei, of the X-bodies in the degenerated synergid.

Planta·2014
Same author

Orchid embryology: Pollen tetrads of Epidendrum scutella in the anther and on the stigma.

Planta·2014
Same journal

TB vaccines at the turn of the century: insights into immunity to M. tuberculosis and modern approaches for prevention of an ancient disease.

Seminars in respiratory infections·2003
Same journal

Environmental infection control of tuberculosis.

Seminars in respiratory infections·2003
Same journal

Mycobacterium tuberculosis: the treatment of active disease.

Seminars in respiratory infections·2003
Same journal

Pediatric tuberculosis.

Seminars in respiratory infections·2003
Same journal

Clinical and radiographic features of HIV-related tuberculosis.

Seminars in respiratory infections·2003
Same journal

Treatment of latent tuberculosis infection.

Seminars in respiratory infections·2003
See all related articles

Area of Science:

  • Infectious Diseases
  • Parasitology
  • Tropical Medicine

Background:

  • Amebiasis, caused by Entamoeba histolytica, is a significant global health concern, ranking as the third leading parasitic cause of death.
  • Invasive amebiasis disproportionately affects immunocompromised individuals, pregnant women, children, and alcoholics, with amebic colitis and liver abscess being common manifestations.
  • Pleuropulmonary complications, such as effusions, empyema, and lung abscesses, frequently arise secondary to liver abscesses.

Purpose of the Study:

  • To review the epidemiology, clinical manifestations, diagnostic challenges, and management strategies for amebiasis, with a focus on its pleuropulmonary complications.
  • To highlight the diagnostic difficulties associated with Entamoeba histolytica detection and the utility of serological and newer immunological tests.
  • To discuss current treatment guidelines, including the role of metronidazole and the indications for abscess drainage.

Related Experiment Videos

Main Methods:

  • Review of existing literature on amebiasis, focusing on invasive disease and extraintestinal manifestations.
  • Analysis of common and unusual clinical presentations, including pleuropulmonary complications and bronchohepatic fistula.
  • Evaluation of diagnostic methods, encompassing direct organism detection, serology, and emerging immunological assays.
  • Summary of established and potential therapeutic interventions, including pharmacotherapy and interventional procedures.

Main Results:

  • Entamoema histolytica infects approximately 500 million people globally, leading to significant morbidity and mortality.
  • Liver abscesses are a common extraintestinal manifestation, frequently preceding pleuropulmonary complications like effusions, empyema, and lung abscesses.
  • Diagnosis can be challenging due to frequent false-negative microbiological results; serological and immunological tests aid confirmation.
  • Metronidazole is the primary treatment; while surgical drainage is generally contraindicated, percutaneous drainage may be necessary for abscesses and empyema.

Conclusions:

  • Amebiasis remains a critical parasitic infection with potentially severe invasive and extraintestinal manifestations, including life-threatening pleuropulmonary complications.
  • Accurate and timely diagnosis is crucial, often requiring a combination of clinical suspicion, microbiological, serological, and immunological investigations.
  • Effective management relies on appropriate antimicrobial therapy, primarily metronidazole, with judicious consideration for drainage procedures in specific complicated cases.