Standard criterion for fluctuations of modulation transfer function in the human eye: application to disposable...

It is well known that the modulation transfer function (MTF) characterizes the optical quality of the eye. Recently, some objective techniques have been introduced in order to measure this function in vivo. These techniques could be employed to display the temporal fluctuations of the eye + compensation system and to isolate the effect of the compensation element provided that the standard fluctuations for a normal observer were known. In this work we carry out a study of the MTF of the human eye over a long period of time to quantify the standard fluctuations of the retinal image quality and to establish a standard criterion of normality. We have defined a single quality parameter from each measured MTF to simplify the analysis of the results. We have evaluated this merit function on normal observers three times a day for one month. As expected, random deviations from the mean value of the merit function have been obtained, although fluctuations with no statistical differences of the merit function (P value from ANOVA test P > 0.01) and the standard deviation of these fluctuations (5%) can be chosen as a standard criterion. We have used this result to study the behaviour of a time-varying compensation element: a disposable contact lens. The study of the eye + contact lens system has been carried out with four types of disposable contact lenses for one month. In spite of their generally good behaviour, statistically significant differences from the standard pattern can be observed. This superimposed continuous fluctuation can be due to lens-dependent processes.