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The malEFG gene cluster of Streptomyces coelicolor A3(2): characterization, disruption and transcriptional analysis
G P van Wezel1, J White, M J Bibb
1Department of Genetics, John Innes Centre, Norwich Research Park, Colney, UK.
Abstract:
The malEFG gene cluster of the Gram-positive mycelial actinomycete Streptomyces coelicolor A3(2) was cloned and sequenced. MalEFG show only limited similarity to homologues involved in maltose and maltodextrin transport in other bacteria. Disruption of malE prevented the utilization of maltose as carbon source. Transcription of malE was induced by maltose and repressed by glucose.