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The role of leukocyte and endothelial adhesion molecules in ischemia-reperfusion injury
R R Thiagarajan1, R K Winn, J M Harlan
1Department of Anesthesia & Critical Care, University of Washington, Children's Hospital & Medical Center, Seattle, USA.
Thrombosis and Haemostasis
|July 1, 1997
Abstract:
Reperfusion of ischemic tissue is associated with an acute inflammatory response that may further exacerbate vascular and tissue damage. Compelling evidence from a variety of animal models indicates that neutrophils are the principle effector cells of the reperfusion injury and that blockade of neutrophil adhesion to endothelium attenuates ischemia-reperfusion injury. "Anti-adhesion" therapy may represent a new approach to treatment of the many diverse clinical disorders in which ischemia-reperfusion occurs.