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[Changes in the nuclear morphometry in oropharyngeal epidermoid carcinoma after induction chemotherapy]
S Santa Cruz Ruiz1, J L Gómez González, T Flores Corral
1Servicio de Otorrinoiaringología y Patologia Cérvico-Facial, Hospital Universitario de Salamanca.
Acta Otorrinolaringologica Espanola
|March 1, 1997
Abstract:
A cytomorphic, stereological study was made by computerized image analysis of six nuclear morphometric variables and one stereological nuclear variable. Variables were measured on 150 randomly selected tumor cells in oropharyngeal biopsies from 44 patients with oropharyngeal cancer who had not responded completely to induction chemotherapy. The nuclei of tumoral cells were larger (mean nuclear area, perimeter, and volume), more rounded, and had a less irregular nuclear contour index.