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[Vasculitis and malignant diseases]

J T Gran1

  • 1Revmatologisk avdeling Regionsykehuset i Tromsø.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|April 30, 1997
PubMed
Summary
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Approximately 1-7% of cutaneous vasculitis patients have associated cancers, often linked to blood cancers. Palpable purpura is a common sign. Suspect malignancy when vasculitis is unexplained by other causes.

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Context:

  • Cutaneous vasculitis affects 1-7% of patients with associated malignancy.
  • Myelo- and lymphoproliferative diseases are frequently associated with vasculitis.
  • Leukocytoclastic or panarteritis nodosa-like vasculitis are common histological types.

Purpose:

  • To explore the association between cutaneous vasculitis and malignancy.
  • To identify clinical and histological features suggestive of malignancy-associated vasculitis.
  • To discuss potential mechanisms of paramalignant vasculitis.

Summary:

  • Malignancy should be suspected in vasculitis cases not fitting defined categories, especially when drugs or infections are ruled out.
  • Palpable purpura is a frequent clinical manifestation.

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  • The discussion includes possible mechanisms underlying paramalignant vasculitis.

    • Impact:

    • Enhances understanding of vasculitis as a potential paraneoplastic syndrome.
    • Aids clinicians in diagnosing malignancy in patients with unexplained cutaneous vasculitis.
    • Highlights the importance of considering cancer in the differential diagnosis of vasculitis.