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Treatment of childhood lymphangiomas with interferon-alpha
M A Reinhardt1, S C Nelson, S F Sencer
1Department of Pediatrics, University of Minnesota Hospitals and Clinics, Minneapolis, USA.
Purpose:
Nonsurgical treatment of lymphangiomas has shown limited efficacy and often carries unacceptable toxicities, demonstrating the need for a more effective, less toxic therapy.
Patients And Methods:
We describe two patients with lymphangiomatosis treated for 12 to 40 months with recombinant interferon-alpha.
Results:
Both patients demonstrated stabilization or marked improvement of disease, based on clinical and radiologic findings, with minimal toxicity.
Conclusions:
The favorable responses to interferon-alpha therapy in these two cases suggest that this is an effective and well-tolerated treatment for lymphangiomas in children.