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DA D2 receptors in the ventral striatum: multiple effects or receptor subtypes?
1Department of Neuroscience, Finch University of Health Sciences, Chicago Medical School, Illinois 60064-3095, USA.
Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology
|April 1, 1997
Summary
Dopamine D2 receptors, not D2, mediate inhibition in the ventral striatum, requiring D1 receptor activation. Dopamine D1 receptors also influence neuronal activity, independent of D2 receptors.
Area of Science:
- Neuroscience
- Neuropharmacology
Background:
- Dopamine (DA) signaling in the ventral striatum is crucial for reward and motivation.
- Dopamine receptors, particularly D1 and D2 families, modulate neuronal activity and function.
Purpose of the Study:
- To review the electrophysiological roles of dopamine D2 and D2 receptors.
- To elucidate the interactions between D2 receptor family members and D1 receptors in the ventral striatum.
Main Methods:
- Electrophysiological recordings in the ventral striatum.
- Pharmacological manipulation using receptor agonists.
Main Results:
- D2 receptor agonists inhibit ventral striatal neurons via D2, not D2, receptors, contingent on D1 receptor co-stimulation.
- D1 receptor agonists' inhibitory effects involve D1 and a D1-like receptor, independent of D2 receptors.
- Dopamine enhances glutamate excitation via co-stimulation of both D1 and D2 class receptors.
Conclusions:
- Dopamine D2 and D1 receptors exhibit distinct and interactive roles in regulating ventral striatal neuronal excitability.
- Specific D2 receptor subtypes mediating effects on sodium currents remain to be identified.