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The apoptotic cysteine protease CPP32

S Kumar1

  • 1Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, Australia.

The International Journal of Biochemistry & Cell Biology
|March 1, 1997
PubMed
Summary
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Caspase-3 (CPP32) is a key protease in apoptosis, activated by death signals. Inhibiting this protease may treat diseases involving excessive cell death.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Caspase-3 (CPP32), also known as Yama and apopain, is a cysteine protease.
  • It belongs to the interleukin-1 beta-converting enzyme (ICE)/CED-3 family of proteases.
  • CPP32 is activated by various death stimuli and plays a crucial role in apoptosis.

Purpose of the Study:

  • To investigate the role of Caspase-3 (CPP32) in apoptosis.
  • To explore the activation mechanisms of CPP32.
  • To assess the therapeutic potential of CPP32 inhibitors.

Main Methods:

  • Characterization of CPP32 activation pathways.
  • Analysis of CPP32's role in processing other ICE family members.
  • Evaluation of CPP32's cleavage of cellular proteins during apoptosis.

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Main Results:

  • Active CPP32 comprises P17 and p12 subunits, derived from a 32 kDa pro-enzyme.
  • Activation can be mediated by ICE-like proteases and granzyme B.
  • Activated CPP32 processes other ICE family members and cleaves cellular proteins in apoptotic cells.

Conclusions:

  • Caspase-3 (CPP32) is a central protease in the apoptotic pathway.
  • Inhibitors of CPP32 and related proteases show therapeutic promise for diseases characterized by excessive cell death, including neurodegenerative and autoimmune disorders.