Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Propofol: pro- or anticonvulsant?

¹Department of Orthopaedics, Klinik Balgrist, University of Zurich, Switzerland.

European Journal of Anaesthesiology. Supplement

|May 1, 1997

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

CCR5 tyrosine sulfation heterogeneity generates cell surface receptor subpopulations with different ligand binding properties.

Biochimica et biophysica acta. General subjects·2020

Same author

Lidocaine inhibits cytoskeletal remodelling and human breast cancer cell migration.

British journal of anaesthesia·2018

Same author

Prevention of arterial hypotension after spinal anaesthesia using vena cava ultrasound to guide fluid management.

British journal of anaesthesia·2018

Same author

Parecoxib, propacetamol, and their combination for analgesia after total hip arthroplasty: a randomized non-inferiority trial.

Acta anaesthesiologica Scandinavica·2016

Same author

Archives of gynecology and obstetrics·2016

Same author

Clinically relevant concentrations of lidocaine and ropivacaine inhibit TNFα-induced invasion of lung adenocarcinoma cells in vitro by blocking the activation of Akt and focal adhesion kinase.

British journal of anaesthesia·2015

Same journal

EuroNeuro 2010. Abstracts of the 6th EuroNeuro Congress. Porto, Portugal. February 4-6, 2010.

European journal of anaesthesiology. Supplement·2010

Same journal

Euroanaesthesia 2003. Abstracts of the joint meeting of the European Society of Anaesthesiologists and European Academy of Anaesthesiology, Confederation of European National Societies of Anaesthesiology, and Association of Anaesthetists of Great Britain & Ireland. May 31-June 3, 2003. Glasgow, Scotland.

European journal of anaesthesiology. Supplement·2008

Same journal

Evoked potentials in the ICU.

European journal of anaesthesiology. Supplement·2008

Same journal

Intracranial pressure monitoring.

European journal of anaesthesiology. Supplement·2008

Same journal

Phrenic nerve stimulation.

European journal of anaesthesiology. Supplement·2008

Same journal

Direct stimulation: a useful technique.

European journal of anaesthesiology. Supplement·2008

See all related articles

Propofol

Area of Science:

Anesthesiology and Pharmacology
Neuroscience

Background:

The anticonvulsant properties of propofol are debated, with conflicting reports of pro- and anticonvulsant effects.
While some case studies suggest proconvulsant activity, systematic research indicates propofol has antiepileptic effects.

Purpose of the Study:

To clarify the controversial role of propofol in seizure activity.
To consolidate evidence regarding propofol's effects on epilepsy.

Main Methods:

Review of systematic studies in humans and animals.
Analysis of propofol's effects during electroconvulsive therapy.
Examination of propofol's efficacy in refractory status epilepticus and animal epilepsy models.

Main Results:

Related Experiment Videos

Propofol consistently reduces seizure duration in electroconvulsive therapy.
Successful control of refractory status epilepticus has been reported with propofol use.
Propofol demonstrates significant protection against induced epilepsy in animal models.

Conclusions:

Systematic evidence strongly supports propofol's antiepileptic properties.
Propofol's benefits may stem from CNS depression, enhanced GABAergic inhibition, and reduced excitatory neurotransmitter release.