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Related Experiment Videos

Propranolol in mitral stenosis during sinus rhythm

S G Meister, T R Engel, G S Feitosa

    American Heart Journal
    |December 1, 1977
    PubMed
    Summary

    Intravenous propranolol effectively reduced pulmonary hypertension in patients with mitral stenosis by lowering heart rate and cardiac output. This suggests a potential role for propranolol in managing this condition in patients with sinus rhythm.

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    Treatment of multifocal atrial tachycardia by treatment of pulmonary insufficiency: or is it vice versa?

    Chest·2000

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Patients with early symptomatic mitral stenosis often experience pulmonary congestion due to elevated left atrial and pulmonary venous pressures.
    • Symptoms typically manifest when heart rate or cardiac output increases, while cardiac output is generally maintained in sinus rhythm.

    Purpose of the Study:

    • To investigate the effects of intravenous propranolol on hemodynamic parameters in patients with pure mitral stenosis in sinus rhythm.

    Main Methods:

    • Intravenous propranolol was administered to patients diagnosed with pure mitral stenosis and in sinus rhythm.
    • Hemodynamic parameters including mitral diastolic gradient, pulmonary pressures, heart rate, cardiac output, and left ventricular systolic pressure were measured.

    Main Results:

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  • Propranolol administration led to significant reductions in mitral diastolic gradient, mean pulmonary wedge pressure, and mean pulmonary artery pressures.
  • These reductions were associated with a decrease in heart rate and cardiac output.
  • A minor decrease in left ventricular systolic pressure was observed without adverse clinical effects.

    • Conclusions:

    • Intravenous propranolol demonstrated a significant impact on reducing pulmonary hypertension in patients with pure mitral stenosis and sinus rhythm.
    • The drug's ability to lower heart rate and cardiac output suggests a potential therapeutic role in the medical management of this condition.