[Study on the interrelationship between human papilloma virus infection and Langerhans cell in carcinogenesis of...

In order to find out the interrelationship between human papilloma virus (HPV) infection and Langerhans cells (LCs) during the development of esophageal carcinoma, and the mechanism of carcinogenesis during HPV infection, digoxigenine labelled HPV DNA probes of HPV 6B/11, HPV 16/18 with in situ hybridization, and anti-S-100 protein antibody with immunohistochemical LSAB-assays were used respectively in order to investigate HPV infection and the distribution of LCs in 40 cases of esophageal squamous cell carcinoma (ESCC). The results showed that there were fewer LC infiltration in HPV-positive cases in comparison with that of the HPV-negative cases. There were also changes about the morphology and distribution of LCs in HPV infected epithelia adjacent to the tumor. The results indicated that HPV infection might inhibit the number of locally LCs infiltrated, destroy the immune surveillance system, and work simultaneously with other carcinogenic factors, in favor of the development of ESCC.