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[A study on cAMP and Ca-CaM of the epithelium in human normal and cataractous lenses]
Abstract
Objective:
The study was designed to study the relationship between calcium-calmodulin (Ca-CaM) and cyclic adenosine monophosphate (cAMP) systems and their possible cataractogenic effects.
Methods:
We measured cAMP, Ca and Ca-CaM in the epithelium of human normal and cataractous lenses by enzymic and radioimmunoassay methods.
Results:
The levels of Ca-CaM in the epithelium of senile cataractous lens were higher, while of cAMP were lower than that in the normal lens.
Conclusion:
The results imply that the low level of cAMP might cause the high level of calcium in the lens which is possibly a cataractogenic factor. The dangerous role of calcium is amplified by the elevation of Ca-CaM.