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[Congenital developmental defects negatively affecting the viability of children of Kursk region: prevalence,
Insights
Congenital defects of development (CD) affected 5.40% of children in the Kursk region from 1985-1994, with higher incidence in urban areas. These defects significantly impacted stillbirths and infant mortality.
Area of Science:
- Pediatric Pathology
- Developmental Biology
- Public Health Epidemiology
Context:
- Study analyzed 4517 autopsy reports from the Kursk region (1985-1994).
- Investigated congenital defects of development (CD) impacting child viability.
- Examined trends and distribution of CD in a defined geographical area.
Purpose:
- To determine the prevalence and temporal trends of congenital defects in children.
- To assess the impact of CD on stillbirths, perinatal deaths, and infant mortality.
- To identify geographical variations in CD incidence within the Kursk region.
Summary:
- Congenital defects of development (CD) were identified in 5.40% of children studied.
- Higher CD incidence observed in urban (6.38%) versus rural (4.91%) areas, particularly in central regions.
- CD accounted for significant proportions of stillbirths (14.53%), perinatal deaths (16.96%), and first-year infant deaths (22.10%).
- Multiple defects and cardiovascular defects were most common, followed by digestive and central nervous system/sensory organ defects.
Impact:
- Highlights the significant burden of congenital defects on child mortality in the Kursk region.
- Provides epidemiological data crucial for targeted public health interventions and resource allocation.
- Informs future research on etiological factors and prevention strategies for congenital defects.
Abstract:
The distribution of and time trends in congenital defects of development (CD) influencing viability of children in the Kursk region were studied on the basis of 4517 autopsy reports for the period 1985-1994. A total of 880 children had CD (5.40%). The incidence of CD in towns (6.38%), was higher than in country regions (4.91%), p < 0.001, being the highest in the central parts of the region. Among the stillborns the specific proportion of congenital defects was 14.53%, perinatal deaths occurred in 16.96%, deaths during the 1st year of life in 22.10%. The percentage of multiple congenital defects, the defects of cardiovascular system, developmental anomalies of digestive system, the defects of central nervous system and organs of sense was 39.77, 27.16, 10.11 and 8.30, respectively.