Antioxidative constituents in Heterotheca inuloides

¹Faculty of Engineering, Fukuyama University, Japan.

|May 1, 1997

Abstract:

Sesquiterpenoids, 7-hydroxy-3,4-dihydrocadalin and 7-hydroxycadalin, and flavonoids, quercetin, kaempferol and their glycosides, isolated from Heterotheca inuloides (Asteraceae), a Mexican medicinal plant known as "arnica", were evaluated as antioxidants. These compounds showed potent scavenging activity on diphenyl-p-picrylhydrazyl (DPPH) radical. Microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH was inhibited by both terpenoids and flavonoids, though only flavonoids possessed superoxide anion scavenging activity in microsome. Flavonoids also scavenged enzymatically and non-enzymatically generated superoxide anion. On the other hand, mitochondrial lipid peroxidation induced by Fe(III)-ADP/NADH was inhibited only by sesquiterpenoids. Furthermore, these terpenes protected mitochondrial enzyme activity against oxidative stress. These results showed that two types of antioxidants existed in the dried flower of H. inuloides and would contribute to protection of tissues against various oxidative stresses.

Related Experiment Videos

Antioxidative constituents in Heterotheca inuloides

Related Concept Videos

Search for the K_{L}→π^{0}νν[over ¯] Decay at the J-PARC KOTO Experiment.

Study of the K_{L}→π^{0}νν[over ¯] Decay at the J-PARC KOTO Experiment.

Search for K_{L}→π^{0}νν[over ¯] and K_{L}→π^{0}X^{0} Decays at the J-PARC KOTO Experiment.

Counterionic Detection by ICP-AES for Determination of Inorganic Anions in Water Elution Ion Chromatography Using a Zwitterionic Stationary Phase.

Steady-state atomic fluorescence radiance expressions for continuum excitation.

Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera.

Criteria-guided selection of alternative zinc-binding groups of HDAC3 inhibitors using in silico and in vitro approaches.

Design, synthesis, and biological evaluation of novel dihydropyrimidinone imines as potent anticancer agents targeting AKT to induce cell cycle arrest and apoptosis in breast Cancer cells.

Design, synthesis, biological and computational evaluation of Thieno[3,2-d]pyrimidine-based inhibitors of JAK3 kinase.

Design, synthesis and biological evaluation of a series of new, potent FLT3 PROTAC degraders with rigid linkers.

An in vitro comparative study of cefiderocol, siderophore-aztreonam and siderophore-daptomycin conjugates against select gram-negative bacteria.

Redirecting MurD inhibitor preference toward MurD2 through glutamate stereochemical inversion.

Structure-activity profiling of indazole-based derivatives as spinster homolog 2 (Spns2)-dependent S1P release inhibitors.

Triterpenoids and lignans from the stems of Tripterygium wilfordii and their hepatoprotective activities.

An integrated in vitro and in silico approach to evaluate the safety and wound healing potential of Dracocephalum moldavica L. seed oil.

Unraveling the allosteric inhibition mechanism of TLR2 by CU-CPT22: A combined DFT and enhanced sampling MD study.

Discovery of pyrimidine-based dual CDK2/TrkA inhibitors: Synthesis, antiproliferative activity, and mechanistic insights.

Oleanolic acid-selenocyanate hybrids trigger replication-associated DNA damage responses and suppress tumour growth in vitro and in vivo.

Related Experiment Videos

Antioxidative constituents in Heterotheca inuloides

Abstract:

Related Concept Videos

Related Articles