Protein kinase C in the postmortem brain of teenage suicide victims

¹Department of Psychiatry, University of Illinois at Chicago, 60612, USA.

|June 6, 1997

Abstract:

Increased serotonin2A (5-HT2A) receptors have been reported in the postmortem brain of suicide victims. To examine if this increase is associated with the dysregulation of postreceptor sites in the signaling cascade, we determined [3H]phorbol dibutyrate (PDBU) binding to protein kinase C (PKC) in postmortem brain samples (Brodmann's areas 8 and 9) obtained from teenage suicide victims and control subjects. [3H]PDBU binding to PKC was determined in membranal and cytosolic fractions. We observed that Bmax of [3H]PDBU binding sites was significantly decreased in both membranal and cytosolic fractions in brain samples from Brodmann's areas 8-9 compared to matched controls. These results thus suggest that PKC may play a role in the pathophysiology of suicidal behavior.

Related Experiment Videos

Protein kinase C in the postmortem brain of teenage suicide victims

Related Concept Videos

Emotional scene processing in biotypes of psychosis.

VGF function in depression and antidepressant efficacy.

Genome-wide association studies of smooth pursuit and antisaccade eye movements in psychotic disorders: findings from the B-SNIP study.

Deviation from expected cognitive ability across psychotic disorders.

Unitary construct of generalized cognitive ability underlying BACS performance across psychotic disorders and in their first-degree relatives.

Panoscopically optimized thermoelectric performance of a half-Heusler/full-Heusler based in situ bulk composite Zr(0.7)Hf(0.3)Ni(1+x)Sn: an energy and time efficient way.

Neural mobilization combined with a polylactic acid conduit enhances functional and morphological recovery following median nerve repair.

How crocodiles lost a forebrain circuit.

Increased CCR2-immunopositive myeloid cells in the putamen and cerebellar white matter with blood-brain barrier disruption in multiple system atrophy.

Anillin functions in distinct glial subtypes to support larval locomotion in Drosophila.

Analysis of the participation and influence of the cerebellum in emotion and emotional memory processing in mice through c-Fos expression.

Varlitinib attenuates neuroinflammation and dopaminergic neurodegeneration in experimental Parkinsonism.

Integrative Network Toxicology Identifies NFKB1 and KIF11 as Candidate Genes Associated with 2-Hydroxyphenanthrene in the Context of Psoriasis.

Network toxicology, molecular docking and molecular dynamics simulations for bisphenol A neurotoxicity in depression pathogenesis.

Small airway dysfunction as a functional barrier to spirometry-defined clinical remission in severe asthma treated with biologic therapies.

Cannabinoid modulation of central amygdala population dynamics during threat investigation.

Development and assessment of an artificial intelligence-based tool for scoring lesion severity in generalized pustular psoriasis clinical images.

In vivo detection of pathologic α- synuclein and TDP-43 in the skin and olfactory mucosa of a patient with Parkinson's disease-like phenotype carrying the p.Thr272Serfs*10 GRN mutation.

Related Experiment Videos

Protein kinase C in the postmortem brain of teenage suicide victims

Abstract:

Related Concept Videos

Related Articles