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The acylation stimulating protein pathway: clinical implications
1McGill Unit for the Prevention of Cardiovascular Disease, McGill University, Montreal, Quebec, Canada.
Clinical Biochemistry
|June 1, 1997
Summary
Acylation stimulating protein (ASP) plays a key role in adipose tissue function. This review details ASP
Area of Science:
- Biochemistry
- Physiology
- Metabolism
Background:
- Adipose tissue is a metabolically active endocrine organ.
- Adipose tissue dysfunction is linked to obesity, diabetes, and heart disease.
- Understanding factors controlling adipose tissue function is crucial.
Purpose of the Study:
- To review the role of acylation stimulating protein (ASP) in adipose tissue.
- To examine the in vitro biochemical characterization of ASP.
- To assess the in vivo clinical relevance of ASP in normal and pathological states.
Main Methods:
- In vitro cell culture studies for biochemical characterization.
- In vivo clinical studies for physiological and pathological relevance.
Main Results:
- ASP exhibits specific biochemical properties in cell culture.
- ASP influences triglyceride and glucose metabolism in adipose tissue.
- ASP's role is significant in both normal physiology and disease states.
Conclusions:
- Adipose tissue is a dynamic metabolic tissue.
- ASP is a key factor influencing adipose tissue function.
- Dysfunctional adipose tissue contributes to metabolic diseases.