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Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease
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Further characterization of a monoclonal antibody recognizing apolipoprotein E peptides in amyloid deposits

T Yamada1, K Wakabayashi, T Kakihara

  • 1Department of Clinical Pathology, Jichi Medical School, Tochig, Japan.

Annals of Clinical and Laboratory Science
|July 1, 1997
PubMed

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...