Related Experiment Video
Updated: Aug 17, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
[Large-cell carcinoma presenting as diffuse thickening of the pleura and resembling malignant mesothelioma]
H Nakamura1, I Ikeda, H Nakahama
1Fifth Department of Internal Medicine, Hyogo College of Medicine, Japan.
Abstract:
A 65-year-old man had a right-sided pleural effusion. A thoracic CT scan revealed diffuse pleural thickening resembling malignant mesothelioma. Repeated needle biopsies did not yield a definitive diagnosis. At autopsy, diffuse pleural thickening was found, and examination of a specimen of lung tissue showed large-cell carcinoma. Hyalinized fibrous tissue with malignant cell infiltration was seen in the thickened pleural tissue and metastatic pleuritis was diagnosed. Large-cell carcinoma of the lung should be considered in the differential diagnosis of pleural thickening.
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