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Granulocyte colony stimulating factor-producing tongue carcinoma
A Horii1, K Shimamura, Y Honjo
1Department of Otolaryngology, Head and Neck Surgery, Osaka Teishin Hospital, Japan.
Background:
Leukocytosis without infection in patients with malignancies is known as the leukemoid reaction. The mechanisms involved in this phenomenon remain uncertain.
Methods:
We describe the clinical, biochemical and immunohistochemical findings in a patient with recurrent tongue carcinoma accompanied by marked leukocytosis as high as 96200/ mm3.
Results:
The serum granulocyte colony stimulating factor (G-CSF) concentration was increased to 204 (normal: < 30) pg/ml, which paralleled to the elevation of white blood cell (WBC) count and the tumor growth. The G-CSF content of the tumor tissue was also elevated (131 pg/mg protein) compared to that in control patients (6.63 +/- 2.63 pg/mg protein). Production of G-CSF from the tumor was evidenced by immunohistochemical staining with monoclonal antibody against human recombinant G-CSF.
Conclusions:
We suggest that the G-CSF production of the tumor participates in the mechanisms of the leukemoid reaction.