The MDA-180 coagulation analyser: a laboratory evaluation

Area of Science:

• Clinical diagnostics
• Hematology
• Laboratory automation

Background:

• The MDA-180 automated coagulation analyser was evaluated in a routine diagnostic hemostasis laboratory.
• The instrument has been in use for over 18 months, processing more than 22,000 samples.

Purpose of the Study:

• To assess the technical performance, ease of use, reliability, and analytical capabilities of the MDA-180.
• To evaluate its ability to perform assays currently done with alternative methods and its potential for streamlining workflows.
• To assess its compatibility with laboratory information systems.

Main Methods:

• The MDA-180 was used in a working diagnostic laboratory environment.
• Over 22,000 samples were processed, with >90% using the cap-piercing function.
• Co-evaluation of assays including PT/INR, APTT, TT, Fibrinogen, Protein C, ATIII, coagulation factors, Lupus anticoagulant (dRVVT), and heparin (alpha Xa).
• Testing of various reagents, particularly for PT and APTT assays.
• Interfacing with the CERNER PATHNET Laboratory Information System.

Main Results:

• The MDA-180 demonstrated remarkable intra-assay and inter-assay precision for PT and APTT.
• Comparative assessments showed good correlation with existing test assay systems.
• The instrument was successfully interfaced with the CERNER PATHNET system.
• Over 90% of samples were processed using the automated cap-piercing facility.

Conclusions:

• The MDA-180 automated coagulation analyser is reliable and user-friendly.
• It is capable of fast sample throughput and accurate analysis of hemostasis assays.
• The instrument is suitable for use in a diagnostic hemostasis laboratory environment.