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Related Experiment Videos

The MDA-180 coagulation analyser: a laboratory evaluation

A Mohammed1, P A Mehrabani, R Coombs

  • 1Department of Hematology, Westmead Hospital, NSW Australia.

Pathology
|May 1, 1997
PubMed
Summary

The MDA-180 automated coagulation analyser demonstrates reliability and ease of use in a diagnostic laboratory setting. It offers fast sample throughput and accurate analytical performance for various hemostasis assays.

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Area of Science:

  • Clinical diagnostics
  • Hematology
  • Laboratory automation

Background:

  • The MDA-180 automated coagulation analyser was evaluated in a routine diagnostic hemostasis laboratory.
  • The instrument has been in use for over 18 months, processing more than 22,000 samples.

Purpose of the Study:

  • To assess the technical performance, ease of use, reliability, and analytical capabilities of the MDA-180.
  • To evaluate its ability to perform assays currently done with alternative methods and its potential for streamlining workflows.
  • To assess its compatibility with laboratory information systems.

Main Methods:

  • The MDA-180 was used in a working diagnostic laboratory environment.
  • Over 22,000 samples were processed, with >90% using the cap-piercing function.

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  • Co-evaluation of assays including PT/INR, APTT, TT, Fibrinogen, Protein C, ATIII, coagulation factors, Lupus anticoagulant (dRVVT), and heparin (alpha Xa).
  • Testing of various reagents, particularly for PT and APTT assays.
  • Interfacing with the CERNER PATHNET Laboratory Information System.

    • Main Results:

    • The MDA-180 demonstrated remarkable intra-assay and inter-assay precision for PT and APTT.
    • Comparative assessments showed good correlation with existing test assay systems.
    • The instrument was successfully interfaced with the CERNER PATHNET system.
    • Over 90% of samples were processed using the automated cap-piercing facility.

    Conclusions:

    • The MDA-180 automated coagulation analyser is reliable and user-friendly.
    • It is capable of fast sample throughput and accurate analysis of hemostasis assays.
    • The instrument is suitable for use in a diagnostic hemostasis laboratory environment.